Partnership with Israel concentrates on Israel's peripheral areas, like the Negev and Galilee, which hold more than two-thirds of Israel's land reserves, yet houses only 17% of the population. The regions' potential for development and immigrant absorption remains largely untapped because of high unemployment rates and weak educational infrastructure.  Partnership with Israel is working to change that.

Today, 27 regions have been matched with 550 Diaspora communities. Nearly every region combines urban centers with neighboring rural peripheries. The principal categories for intervention are immigrant absorption and population growth, job creation and human needs. Its goal is to partner Jewish communities worldwide with regions in Israel to create people-to-people relationships between Israeli and Diaspora Jews.

Since its inception in 2000, countless children, teenagers and adults in Michiana have enjoyed the benefits of shared arts programs and joint American-Israeli classroom projects through Partnership with Israel. The Michiana community has helped with the mitzvah of developing the regional security and state-of-the-art hospital and medical facilities, and has also been able to send local medical professionals to the region for Emergency Medical training. Partnership with Israel also is dedicated to helping Michiana teenagers visit Israel and the Partnership Region.